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If (and only if) liver uptake cannot keep with production, unconjugated bilirubin concentrations will increase in blood (this depends on the rate and degree of hemolysis and underlying hepatic function, which can vary between animals)

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Melanin is what makes the skin colour, and in case of excess production or unevenness, dark spots and pigmentation would be observed

Notably, no significant increase was observed for older GLP-1 medications like liraglutide, dulaglutide, exenatide, or lixisenatide

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