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Giovannoni G, Comi G, Cook S, Rammohan K, Rieckmann P, Soelberg Srensen P, et al

reported that lipid peroxidation product 4-HNE inhibited pyroptosis and inflammasome activation of LPS stimulated macrophages (M1 macrophage) by directly disrupting the binding of NIMA-related kinases 7 to NLR Family Pyrin Domain Containing 3 (NLRP3) ( Different cytokines secreted by macrophages also have distinct effects on lipid peroxidation

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Mechanism: Acts as a signal peptide that modulates fibroblast activity, collagen and glycosaminoglycan synthesis, antioxidant signaling, and copper bioavailability [1][2]

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