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The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline
van der Rijt, S., Leemans, J
Intracellular GSH levels and the expression of antioxidant enzymes (NRF2, GPX4 and SOD1) were evaluated in tumor tissues in 51 patients receiving neoadjuvant chemotherapy
The first domain is responsible for GSH binding, with the presence of a specific binding task which is termed G-site
The intermediates from de novo lipogenesis in the liver will disrupt mitochondrial function and produce ROS, and then cause endoplasmic reticulum (ER) stress, ultimately leading to inflammation, and the broken cells releasing cytokines will cause more cell death (Huang et al., 2025)
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