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[PMID: 8866249] PubMed record related to this compound for laboratory literature review
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The cGAS-STING pathway is a major cytosolic DNA-sensing pathway, where cGAS detects foreign DNA and synthesizes cyclic GMP-AMP, which then binds to and activates STING
Increased AMP levels activate Adenosine Monophosphate-Activated Protein Kinase (AMPK), which contributes to lowering of glucose production by at least 2 pathways: i) increased AMPK phosphorylates CBP & CRTC2 transcription factors, which inhibits genes involved in the production of glucose (gluconeogenic genes)
Most commercial preparations contain 1000 mcg of vitamin B12 per mL, making it easy to figure out the dosage volume
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