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Fatima T, Jacobsson L, Kern S, et al
Abstract Drug development for the treatment of central nervous system (CNS) diseases is extremely challenging, in large part due to the difficulty in crossing the blood-brain barrier (BBB)
Peripherally, pancytopenia is most often observed, but only 1-2 of the major cell types (erythrocytes, leukocytes, platelets) may be depressed in some cases
This constant histamine release drives systemic inflammation, allergic flares, gastrointestinal distress, and severe neurological symptoms like brain fog and neuropathic pain
Segel IH (1993) Enzyme kinetics
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