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Is sertraline (an SSRI antidepressant) safe to use concurrently with tirzepatide (a GLP1/GIP receptor agonist)?

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However, the recently concluded SAVOR-TIMI 53 trial conducted on patients with T2DM with either a history of established CVD or multiple CVD risk factors, has failed to demonstrate the superiority of saxagliptin over placebo in reducing a composite end point of cardiovascular death, nonfatal MI or nonfatal ischemic stroke when added to usual care [142, 143]

It's a one-to-one relationship

We confirmed these observations in human islets