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For example, in a recent cross-sectional surveillance study conducted in 43 paediatric patients taking VPA [48], only two were found to have carnitine levels below the normal limit, suggesting that routine carnitine level checking is not justified
The study group comprised 153 patients, while the control group included 362 patients
Researchers are continuing to evaluate this effect to better understand its significance and potential impact on long-term treatment safety
In summary, pathological stimulation triggers excessive Ca release from the ER and disrupts mitochondrial function, thereby impairing Ca uptake and reducing ATP production
doi: 10.1038/s41598-021-88108-8 6 YabeDSeinoYFukushimaMSeinoS
