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They disrupt fundamental cellular processes, including energy production, insulin signaling, glucose metabolism, and mitochondrial function, at times contributing to cognitive decline, fatigue, reduced ability to fight infections, and increased chronic disease risk

Tesamorelin showed to be effective in reducing liver fat in HIV- infected patients with abdominal fat accumulation [3]

In NDI1-expressing adipocyte- Bmal1 KO mice, we also observed reduced hepatic steatosis, smaller white adipocyte size and restored ratios of NAD + -to-NADH and ATP-to-ADP (Extended Data Fig