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A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric no-dependent and gut-brain axis mechanism

The six case reports in the paper demonstrated the wide range of effects these drugs can have

Two samples were removed from vehicle group, i.e., one sample was non-detectable and for another sample the activity was a significant outlier (Grubbs test)

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Consequently, it is essential to prioritize shared decision-making and individualized risk-benefit assessments for prescribing GLP-1 RAs, while avoiding misuse with off-label indications