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Cell Metabolism 2022: 10.1016/j.cmet.2022.07.013 cAMP functional potency, low-receptor-density assays (GIP EC50 0.0643 nM, GLP-1 0.775 nM, glucagon 5.79 nM

This desensitization is more theoretical than dramatically demonstrated in research, but most experienced practitioners recommend cycling to maintain optimal responsiveness

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We are in the early stages, and we need better protocols