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Glutathione dysregulation and the etiology and progression of human diseases

Eder T, Weber A, Neuwirt H, Grunbacher G, Ploner C, Klocker H et al

Relative mRNA expression of Gclm (p = 0.0026), Hmox1 , Nqo1 , and Slc7a11 (d) and representative immunohistochemistry of indicated proteins (e) in Gclc WT and Gclc KO tumors (n = 6 representative from 3 independent experiments)

doi: 10.1038/s41591-020-01195-4 138 ZhouHLeiPJPaderaTP

Furthermore, based on the western blot results, we found that the protein level of the ACSL4 was elevated, whereas GPX4 and xCT protein levels were reduced in lung tissues of OVA-induced asthmatic mice in comparison with controls, which was significantly reversed by SMAD4 silencing (Fig