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Many chronic migraine patients also have tenderness throughout their shoulders, and many have associated fibromyalgia
Many cardiovascular risk factors such as diabetes mellitus, hypertension and hyperlipidemia are demonstrated to stimulate the interaction of Cav-1 and eNOS, reduce nitric oxide production resulting in endothelial dysfunction and subsequently the formation of atherosclerotic lesion 41,42,43
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Recent systematic reviews have demonstrated high quality evidence for use of ESIs for management of lumbar radicular pain
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