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The FDA approved once-daily oral semaglutide (Wegovy) at 25 mg on 22 December 2025, making it the first oral GLP-1 approved specifically for chronic weight management in the US

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M., Sackesen, C., Erzurum, S

They do not rebuild the system required for metabolic resilience, a system that sits at the center of GLP-1 microbiome science and is powered primarily by the gut microbiome, SCFAs, inflammation control, circadian timing, and mucosal structure

It is being studied for the treatment of T2DM, Obesity, Osteoarthritis , and Obstructive Sleep Apnea with a planned simultaneous submission strategy