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Rank N, Michel C, Haertel C, et al

For individuals on thyroid hormone replacement therapy , significant weight loss can lead to an overdose of thyroid hormones , resulting in thyrotoxicosis and severe complications like atrial fibrillation

However, similar protective effects were not observed in other racial groups or Hispanic populations, potentially attributable to limited statistical power in these subgroup analyses [19]

Clinically significant abnormalities in vital signs, laboratory evaluations, ECG recordings and physical examinations were recorded as adverse events and followed-up as appropriate