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It does this by inactivating it

52 Similarly, the odds of at least 5-, 10-, 15- and 20-point improvements in all KCCQ domains were 1.6- to 2.9-fold higher among semaglutide- than placebo-treated patients

Semaglutide: GLP-1liraglutide(Saxenda)Semaglutide(Wegovy)12 (1218BMI30kg/m2)60kg 3.0mg12 (BMI)4% 2.4 mg 12 (BMI) 5% 2023 GLP-112 611Liraglutide20249NEJM 5646%BMI5.8%1.6%P 27 GLP-1 GLP-1 A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity N Engl J Med 2020

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