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PMID: 23876621 | doi:10.1016/j.tig.2013.06.007 Caputi S et al

A trial showing 8% mean body-fat reduction in a European cohort should not be assumed to replicate identically in a Japanese cohort without attention to ADRB3 allele distribution

This usually includes: Looking at how you responded to your current medication to choose the right starting dose for the new one

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From this, results will then last on average for two years