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Cold Spring Harb Perspect Biol (2012) 4:a006049.10.1101/cshperspect.a006049 29 BarjestehNBehboudiSBrisbinJTVillanuevaAINagyESharifS
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions
For Biomarker Research, the most promising direction is not a single universal metabolite but a phenotype-aware, pathway-anchored biomarker strategy that integrates circulating metabolites with imaging, clinical context, and validated outcomes
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