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The lack of adequate cobalamin in the body hinders the regeneration of tetrahydrofolate, which eventually leads to megaloblastic anemia due to the functional folate deficiency.[9][10] On the other hand, the methylmalonyl-CoA mutase helps to metabolize odd chain fatty acids and branch chain amino acids.[5] Cobalamin is also thought to keep the bodys level of sulfhydryl (SH) groups in reduced form

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Saxenda also positively influences insulin response and post-meal glucose control

Until then, retatrutide is available only through research channels and compounding sources

Hepatology 76 , 869887 (2022)