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It may also be prescribed for people with a BMI of 27 or higher who also have weight-related health issues such as high blood pressure, high cholesterol, or type 2 diabetes

Potential areas of expansion include: Cardiovascular outcomes: A dedicated CVOT, if not already required as a post-marketing commitment, would evaluate whether orforglipron reduces MACE in patients with established cardiovascular disease or high cardiovascular risk, following the precedent set by the SELECT trial for semaglutide

The switching process from tirzepatide to semaglutide requires careful dose management

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