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Translationally, this perspective supports structured evaluation of micronutrient status aimed at maintaining enzymatic capacity rather than indiscriminate supplementation

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In this work, we investigate the molecular mechanisms by which GLP-1, oxyntomodulin, exendin-4, and exendin-P5 bind and activate the GLP-1R using a combination of structural biology, molecular dynamics simulations, and pharmacological studies combined with extensive receptor mutagenesis

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