The effect of OVX over mitochondrial functions appears to be related to changes in the fatty acid profile of the mitochondria membrane, where cardiolipin is reduced and more exposed to peroxidation (Kemper et al., 2013
In the CT-like conformation, the bypass motif becomes unstructured, and residues (S21-P28) are not well resolved, suggesting this flexible segment is exposed to the solvent environment
We are also bombarded with daily stress, encountering bacteria/viruses, lack of sleep, lack of sunshine, and inadequate exercise, which all contribute to cellular stress and compromised immune system function
Consult a doctor if symptoms develop.
Examples of GLP-1 drugs include semaglutide (found in Ozempic and Wegovy), tirzepatide (found in Mounjaro and Zepbound) or liraglutide (Saxenda and Victoza)