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Trp53 fl/fl ) or intracolonic induction of colon tumours by submucosal injection of 100 M 4-hydroxytamoxifen (Sigma-Aldrich) in 810-week-old AKP mice (Villin-CreER T2

(2) If dialysis is used, this will remove acetylcysteine, thereby aggravating the mismatch between acetylcysteine dose vs

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The mechanism enhanced phospholipid turnover and methyl donor availability operates continuously but produces gradual rather than acute effects