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Moreover, patients with AA generally have fewer comorbidities than those with rheumatoid arthritis, and rates of serious infections, HZ, MACE, venous thromboembolism (VTE), and malignancy are lower in dermatologic vs rheumatologic populations.25 Overall, IRs for MACE and VTE in the ALLEGRO clinical program were 0.14/100 PY and 0.06/100 PY, respectively

Elevated GH during sleep promotes slow-wave sleep architecture, collagen synthesis, and cellular repair processes that are central to anti-aging protocols

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Importantly, insulin resistance worsens with age even in individuals without overt disease, reducing metabolic resilience and elevating lifetime risk