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BMC Gastroenterology

Subgroup analyses revealed that weight loss was greater in overweight versus obese participants, in unhealthy versus healthy participants, with daily doses 600 mg, and for intervention period shorter than 10 weeks

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After treating human hepatocytes with prednisolone, the active metabolite of prednisone, and CsA at concentrations ranging from 0.5 to 100 M for 96 h, the incubation medium was replaced with 100 M 4-trifluoromethyl-7-hydroxycoumarin and 100 M -estradiol, which are probe substrates of UGT1A9/2B7 and UGT1A1/1A3, respectively, for an additional incubation of 30 min