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Although it is effective in targeting cancer cells, it can alter many other tissues like CNS and GI tissue (Yang Q

This provides a rationale for the effect of mutagenesis of R190 2.60 and K197 2.67 , which were two of the few TMD residues that had a large impact on exendin-P5 affinity (Supplementary Figs 5 and 9)

Respiratory Res

Although studies on the relationship between HO-1 and macrophages in diabetes or its complications are limited, the mechanisms by which macrophages maintain the microenvironment stability of the body and HO-1s excellent antioxidant and anti-inflammatory properties suggest that targeting HO-1 with macrophages may be a treatment choice for diabetes (Fig