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[1] In the SURMOUNT-1 clinical trial, higher doses in non-diabetic adults demonstrated significant weight loss, with participants losing approximately 15-20% of body weight over 72 weeks

or after systemic injection

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Furthermore, RNA sequencing analysis revealed that LPS induces comprehensive alterations in androgen synthesis pathways by regulating cholesterol metabolism (e.g., 3-hydroxy-3-methylglutaryl-CoA reductase (rat gene Hmgcr)) and inflammation-related genes