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Such a robust fibrosis can be induced in rodents with prolonged or repeated exposure to certain chemicals (carbon tetrachloride, alcohol, tetrachlorovinphos, diallylphthalate), dietary lipotrope deficiency, or chronic hepatitis secondary to persistent infection (Ward 1997)
This has not been demonstrated in animal studies, but the mechanism warrants caution
In Vivo Inhibition of Angiogenesis by Interleukin-13 Gene Therapy in a Rat Model of Rheumatoid Arthritis
10 Reduced glutathione is associated with higher oxidative stress, 11 which contributes to damage 12 in the trabecular meshwork cells and retinal ganglion cells, worsening glaucoma and accelerating optic nerve damage
And that's where our central question comes roaring back into focus
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