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On one hand, the cardiovascular protection afforded by SGLT2is seems to result from their beneficial hemodynamic effects, including improvement in ventricular preload (secondary to natriuresis and osmotic diuresis) and afterload (through blood pressure reduction), but also from improvement of cardiac metabolism (through the switch from utilization of glucose to ketones), inhibition of the myocardial Na + /H + exchanger, reduction of cardiac fibrosis and necrosis, reduction of proinflammatory adipokines derived from epicardial and perivascular fat, and stimulation of erythropoiesis (which can facilitate the release of oxygen to ischemic tissues) [1, 4, 14,15,16]
For both pills tested, researchers saw side effects similar to those associated with other GLP-1 drugs: some nausea, vomiting, diarrhea and constipation
Diabetes Obes Metab 24(6):969982
2) 3) 4) 5) 6) About the Author Originally authored by Thomas Jadallah
Once GHRH is in play, it beckons the pituitary gland to release growth hormone
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