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J Clin Psychiatry 85:50515 Samms RJ, Christe ME, Collins KA et al (2021) GIPR agonism mediates weight-independent insulin sensitization by Tirzepatide in obese mice

However, several indirect considerations are relevant

Nausea is the most common reason for dose adjustments, but it usually resolves within 24 weeks

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Its known to be the most effective way to treat a deficiency simultaneously