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A 2021 study in Biochemical Pharmacology examining AHK-Cu's effect on TNF- and IL-6 expression in LPS-stimulated macrophages used 300mcg administered intraperitoneally, achieving statistically significant reductions in pro-inflammatory markers at 4, 8, and 12 hours post-administration

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V itamin B12 : Research on vitamin B12 suggests that it can reduce the severity of migraine with aura