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Her patients already email asking to be upgraded to retatrutide after hearing about it on TikTok, even though she cannot prescribe it because it does not exist as an approved drug
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This absence of formal research means that any combined use is based on extrapolation from individual drug studies, theoretical pharmacology, and anecdotal clinical experience rather than robust evidence
Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes that has gained widespread use for weight management
It increases GLP-1 and another hormone called glucose-dependent insulinotropic polypeptide (GIP) This means it works in two ways while semaglutide only mimics GLP-1 hormones, tirzepatide also mimics GIP hormones
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