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Mechanistic studies would be strengthened by isoform-specific NOS experiments, FAK or paxillin pathway inhibition, VEGFR2 pathway modulation, direct measurement of endothelial and fibroblast markers, and rescue experiments that test whether blocking one pathway prevents downstream effects
That is why it is important to use gentle products and follow careful aftercare to reduce irritation, prevent breakouts, and support skin healing
However, these drugs are also approved to treat other conditions
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