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In contrast, sustained or excessive ROS accumulation suppresses AMPK activity by destabilizing the AMPK-LKB1 complex, inducing inhibitory Ser485/491 phosphorylation via Akt/PKA signaling, and causing irreversible oxidative modifications of key cysteine residues (Yan et al., 2022)
It was originally isolated from rabbit brain
Folia Biologica (Praha)
PMC 2223905
Glutathione S-Transferase Recombinant, His Tag
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