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Firstly, some people believe that cerebral insulin resistance in patients with AD may not be insulin resistance in the true sense of the word but may instead arise from dysfunctional insulin transport across the BBB and that this transport defect may be caused by abnormal BBB function indirectly resulting from peripheral insulin resistance (Arnold et al., 2018)

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Electrostatic interactions were calculated with the Particle-Mesh Ewald (PME) algorithm 48 with a real-space cut-off of 1.2 nm