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(2) This is distinct from the activity of other GHSs, which often also engage with receptors related to ACTH or cortisol

They should be viewed as complementary lifestyle strategies rather than direct substitutes for pharmacotherapy when medication is clinically indicated

Evaluate gut function and correct constipation or dysbiosis before starting long-term hormonal therapy

Mechanistically, Iso reduced ROS and MDA levels, enhanced SOD and CAT activity, and suppressed the NOX4/ROS/NF-B pathway by promoting Nrf2 nuclear translocation (Dai et al., 2018)

J Basic Clin Physiol Pharmacol