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Pfizer reported that its dose-optimization studies of once-daily formulations of danuglipron met key pharmacokinetic objectives and confirmed a formulation and dose with the potential to deliver a competitive efficacy and tolerability profile in Phase III testing, based on earlier studies of twice-daily danuglipron
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To determine the consequences of these tissue-specific modifications in antioxidant capacity, we measured the levels of protein carbonyls, MDA (a product of lipoperoxidation reactions) and nitro-tyrosine (NO 2 -Tyr) as markers for biomolecule oxidative damage (Fig
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