However, the lipoatrophic diabetes observed in patients with lipodystrophies differs significantly from common type 2 diabetes in several regards, typically with significantly reduced adipose mass, dysregulation of adipose derived hormones including leptin and adiponectin, dyslipidaemia, more severe insulin resistance and significant hyperinsulinemia (2, 4, 6)
There is one FDA-approved oral semaglutide (Rybelsus) for diabetes, which requires specific administration on an empty stomach
It is available as a research compound
Link Dimpfel, W., Storni, C., & Verbruggen, M
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