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Any use outside of research falls into a legal gray area

~ AlphaMD Many people associate nicotine primarily with smoking and tobacco use, but with the growing popularity of nicotine gum, patches, and other alternatives, questions arise about how nicotine itself affects the body

Common signs include persistent fatigue (even after a full nights sleep), brain fog, mood swings or irritability, numbness or tingling in the hands or feet, and a weakened immune system

This side effect can be uncomfortable but is generally not serious if treated promptly

The breadth of data was presented during a late-breaking symposium at the 2026 Scientific Sessions of the American Diabetes Association (ADA) in New Orleans, June 58, alongside the simultaneous publication of REIMAGINE 1 and 2 trial results in The Lancet Diabetes & Endocrinology and the REIMAGINE 3 trial results in The Lancet