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For diabetes treatment, NICE recommends continuing GLP-1 therapy only if HbA1c has fallen by at least 11 mmol/mol (1%) and weight has reduced by at least 3% after approximately 6 months, unless there are individual clinical reasons to continue

Discontinuing Semaglutide or Tirzepatide Semaglutide and Tirzepatide are l ong-term treatments for obesity rather than cures

These chemicals are called prostaglandins, which play a role in pain, fever, and swelling

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This precaution relates primarily to the gastroparesis effect of GLP-1 drugs, which slows gastric emptying