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2) The results of this study completed by McCoy et al systematically evaluated the metabolic stability, BBB permeability, procognitive activity, and synaptogenic potential of Dihexa and other Nle-AngIV analogs, ultimately aiming to identify a therapeutic agent for dementia
PubMed Jett, L., Lger, R., Thibaudeau, K., Benquet, C., Robitaille, M., Pellerin, I., Paradis, V., van Wyk, P., Pham, K., & Bridon, D.P
201801609 DOI: 10.1073/pnas.1801609115
This, in turn, contributes to a reduction in antioxidant capacity
The peptide carries a C20 fatty diacid moiety that extends its half-life, allowing once-weekly administration
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