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Persistent epigenetic differences associated with prenatal exposure to famine in humans
Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models
The toxicity of busulfan is caused by its irreversibile glutathionylation played by GSTs
doi:10.1155/2015/648108 Staresinic M, Sebecic B, Patrlj L, et al
However, the landscape is shifting
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