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32 Efflux lowers the intracellular drug concentration below inhibitory levels
Since Wegovy already slows gastric emptying, adding alcohol which can irritate the stomach lining and cause nausea may intensify gastrointestinal side effects
Community use of research retatrutide often starts at lower doses to assess GI tolerability
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Dose increases typically land every 4 weeks, and each step up often brings a fresh round of nausea or fatigue for several days
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