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Longevity protocol: Dose: 0.5-1mg daily (lower end) Frequency: 3-5 times weekly Cycle: 8 weeks on, 4 weeks off, indefinite repetition Combine with: Overall health optimization (sleep, nutrition, exercise) Lower doses for longevity reduce cost and theoretical concerns about long-term copper peptide use while potentially maintaining meaningful benefits

For context, the CSF exposure of monoclonal antibodies used in Alzheimers disease typically ranges from 0.1% to 0.3% of plasma concentrations, whereas small-molecule CNS drugs often exceed 5%, placing semaglutide within a low but pharmacologically plausible exposure range

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B, patients in Optimize It and Shed It benefit from having a single dedicated platform for all aspects of dual treatment

The receptor dimer then associates with ERE (Estrogen Receptor Element), this in term recruits and modulates the so-called co-regulatory proteins namely co-activators and co-repressors