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5 Biodistribution Compound concentrations are typically determined in serum or plasma, although the systemic circulation is not necessarily the pharmacodynamic target compartment
Prevention of oxaliplatin-related neurotoxicity by -3 pufas: a double-blind randomized study of patients receiving oxaliplatin combined with capecitabine for colon cancer
Who should avoid it Pregnant or breastfeeding women should avoid it due to insufficient safety data
For example, a Cleveland Clinic study from June 2025, involving 7,881 participants, found that high-dose tirzepatide users lost 18.0% of their body weight in one year, semaglutide users lost 13.7%, and those who discontinued early (within three months) lost just 3.6%
Instead, the arrival of oral GLP-1s is likely to attract needle-hesitant patients, effectively expanding the total addressable market (TAM) rather than displacing the existing one
