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After stopping the supplement, symptoms tended to return, suggesting the improvement was indeed due to Pycnogenol
Loss or mutation of p53 disrupts these pathways, promoting cellular immortalisation, checkpoint defects, and genomic instability, which allows replication of damaged DNA and contributes to tumourigenesis (35, 36)
It should be swallowed whole with a sip of water (up to half a glass of water equivalent to 120ml)
It is also used for fibromyalgia, rosacea, and other illnesses, although there is little evidence supporting these claims
Most of these caffeine side effects can be attributed to the stimulant effects of the drug on the body and are usually related to the dose consumed
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