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For example, considering HepG2, Huh7, and Hep3B, even though they are all epithelial liver cancer cells with high expression of HNF4, HepG2 cells have normal expression of wild-type p53, Huh7 cells overexpress a mutant p53, while Hep3B cells are p53 null 65
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Of a particular interest, poly(lactide-co-glycolide) (PLGA) is a biocompatible and biodegradable polyester, which is used in several FDA-approved products in the form of microspheres and other pharmaceutical dosage forms 2,3
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