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These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

The powder requires reconstitution with bacteriostatic water before administration

doi: 10.2337/db13-0893 168 BergmannNCGasbjergLSHeimbrgerSMKroghLSLDelaFHartmannBet al