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Considering their mechanism of action, there is a rationale for using GLP-1 agonists in conditions such as dumping syndrome to slow gastric emptying, diarrhoea-dominant IBS, bile acid diarrhoea due to their potentiation of the ileal brake mechanism18 or even short bowel syndrome and high output stomas.19 These are currently not licensed indications nor have any trials been undertaken to date
About Ergomax
5-Amino-1MQ is a substrate-mimetic inhibitor occupying the nicotinamide binding site, with a reported IC of 1.2 0.1 M (Neelakantan et al., J Med Chem, 2017)
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