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doi: 10.1016/S2213-8587(19)30311-0 31 ZinmanBBhosekarVBuschRHolstILudvikBThielkeDet al
Examples Pioglitazone (Actos) Dosage Initial: 1530 mg once daily Maximum: 45 mg daily Rosiglitazone (Avandia) Dosage Initial: 4 mg daily as a single dose or in two divided doses Maximum: 8 mg daily as a single dose or in two divided doses Possible side effects include: Weight gain Fluid retention (edema), including macular edema Increased risk of heart failure (related to fluid retention) Osteoporosis and bone fracture Possible increased risk of bladder cancer with pioglitazone Alpha-glucosidase inhibitors Primary mechanism(s) of action Inhibition of intestinal -glucosidase and pancreatic -amylase, which reduces carbohydrate absorption
These numbers drop down when accounting for side effects: 72% of Americans would use GLP-1 drugs if there were no side effects, which falls to 52% if there are side effects
10.1038/s41598-018-21933-6 Sci
Most cases are mild and resolve within 4-8 weeks as your body adapts to the medication
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