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However, clinicians should recognize that any use of GLP-1 agonists in Crohn's disease patients remains off-label and requires careful consideration of the established evidence base for IBD management

Side effects are typically mild and short-lived, and current research suggests no significant organ toxicity at therapeutic doses over the long term

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Metformin, the prescription medicine for type 2 diabetes, may have similar features to berberine supplements regarding glucose metabolism

On the other hand, in the Si-DSS group, only a few macrophages were observed in the submucosa of the rectum on the 3rd day after DSS treatment, and almost no macrophages were observed in the colon (Fig